ウェビナー動画：ジスルフィド結合の特性解析における課題を克服する革新的な質量分析データ処理ソリューション

質量分析（MS）は高感度で分子レベルの詳細な情報を得られるため、ジスルフィド結合の緻密かつ確実な特性解析を可能にする一方で、膨大かつ複雑なデータの処理が課題となります。本動画では、MSを用いたジスルフィド結合の特性解析を大幅に加速する方法を紹介しています。

Disulfide bonds are essential for maintaining the structural integrity, stability and biological activity of many therapeutic proteins and are therefore classified as a critical quality attribute. Identification and monitoring of expected disulfide linkages and their scrambled counterparts are key to ensuring efficacy and safety in the development of protein-based therapeutics. While spectroscopic and electrophoretic methods are available, mass spectrometry (MS)-based analysis has emerged as the predominant analytical technique.

Providing high sensitivity and detailed information at the molecular level, MS enables thorough and confident characterization of a product’s expected and scrambled disulfide linkages, but also presents several challenges such as:

• Complex data requiring extensive manual interpretation by expert users.
• A combinatorial explosion of possible candidates leading to long, indefinite data processing times.
• An extensive search space further complicated by cysteine-related linkages besides disulfides, including thioethers and trisulfide impurities.

In this webinar, learn how Genedata Expressionist offers a cutting-edge software solution designed to overcome these challenges, significantly accelerating and streamlining the in-depth characterization of disulphide linkages.

Speaker: Stephen Kok, Scientific Consultant – Genedata Inc., San Francisco, CA, USA